Project publications

1. Araújo JR, Tomas J, Brenner C, Sansonetti PJ. Impact of high-fat diet on the intestinal microbiota and small intestinal physiology before and after the onset of obesity. Biochimie. 2017;141:97-106.


2. Assinger A, Wang Y, Butler LM, Hansson GK, Yan ZQ, Söderberg-Nauclér C, Ketelhuth DF. Apolipoprotein B100 danger-associated signal 1 (ApoBDS-1) triggers platelet activation and boosts platelet-leukocyte proinflammatory responses. Thromb Haemost. 2014 Aug;112(2):332-41.


3. Brauner S, Jiang X, Thorlacius GE, Lundberg AM, Östberg T, Yan ZQ, Kuchroo VK, Hansson GK, Wahren-Herlenius M. Augmented Th17 differentiation in Trim21deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content. Cardiovasc Res. 2018 Jan 1;114(1):158-167.


4. Eken SM, Jin H, Chernogubova E, Li Y, Simon N, Sun C, Korzunowicz G, Busch A, Bäcklund A, Österholm C, Razuvaev A, Renné T, Eckstein HH, Pelisek J, Eriksson P, González Díez M, Perisic Matic L, Schellinger IN, Raaz U, Leeper NJ, Hansson GK, Berne G, Hedin U, Maegdefessel L. MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions. Circ Res. 2017 Feb 17;120(4):633-644.


5. Gisterå A, Hansson GK. The immunology of atherosclerosis. Nat Rev Nephrol. 2017 Jun;13(6):368-380.


6. Gisterå A, Hermansson A, Strodthoff D, Klement ML, Hedin U, Fredrikson GN, Nilsson J, Hansson GK, Ketelhuth DF. Vaccination against T-cell epitopes of native ApoB100 reduces vascular inflammation and disease in a humanized mouse model of atherosclerosis. J Intern Med. 2017 Apr;281(4):383-397.


7. Johansson ME, Ulleryd MA, Bernardi A, Lundberg AM, Andersson A, Folkersen L, Fogelstrand L, Islander U, Yan ZQ, Hansson GK. α7 Nicotinic Acetylcholine Receptor Is Expressed in Human Atherosclerosis and Inhibits Disease in Mice. Arterioscler Thromb Vasc Biol. 2014 Oct 16.


8. Johansson ME, Zhang XY, Edfeldt K, Lundberg AM, Levin MC, BorÚn J, Li W, Yuan XM, Folkersen L, Eriksson P, Hedin U, Low H, Sviridov D, Rios FJ, Hansson GK, Yan ZQ. Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic mice. Eur J Immunol. 2014. Oct;44(10):3081-92.


9. Karadimou G, Folkersen L, Berg M, Perisic L, Discacciati A, Roy J, Hansson GK, Persson J, Paulsson-Berne G. Low TLR7 gene expression in atherosclerotic plaques is associated with major adverse cardio- and cerebrovascular events. Cardiovasc Res. 2017 Jan;113(1):30-39.


10. Kiamehr M, Viiri LE, Vihervaara T, Koistinen KM, Hilvo M, Ekroos K, Käkelä R, Aalto-Setälä K. Lipidomic profiling of patient-specific induced pluripotent stem cell-derived hepatocyte-like cells. Dis Model Mech. 2017, 10(9):1141-1153. [Epub 2017 Jul 21].


11. Lee, G., Espirito Santo, A.I., Zwingenberger, S., Cai, L, Vogl, T., Feldmann, M., Horwood, N., Chan, J. and Nanchahal, J. Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert. Proc. Natl. Acad. Sci. USA. 2018 (in press).


12. Lundberg AK, Jonasson L, Hansson GK, Mailer RKW. Activation-induced FOXP3 isoform profile in peripheral CD4+ T cells is associated with coronary artery disease. Atherosclerosis. 2017 Dec;267:27-33.


13. Mailer RKW, Gisterå A, Polyzos KA, Ketelhuth DFJ, Hansson GK. Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population. Sci Rep. 2017 Nov 15;7(1):15655. PMC5688061.


14. Mailer RKW, Gisterå A, Polyzos KA, Ketelhuth DFJ, Hansson GK. Hypercholesterolemia Induces Differentiation of Regulatory T Cells in the Liver. Circ Res. 2017 May 26;120(11):1740-1753.


15. Nanchahal, J., Ball, C., Swettenham, J., Dutton, S., Barber, V., Black, J., Copsey, B., Dritsaki, M., Taylor, P., Gray, A., Feldmann, M. and Lamb, S. Study protocol: a multi-centre, double blind, randomised, placebo-controlled, parallel group, phase II trial (RIDD) to determine the efficacy of intra-nodular injection of anti-TNF to control disease progression in early Dupuytren’s disease, with an embedded dose response study. Wellcome Open Research, 2017, 2: 37.


16. Stefano Manzini, Leena E. Viiri, Suvi Marttila, Katriina Aalto-Setälä. A Comparative View on Easy to Deploy non-Integrating Methods for Patient-Specific iPSC Production. Stem Cell Reviews and Reports. 2015Sept; pp 1-9.


17. Mohammad Ali, Ashish Saroha, Yael Pewzner-Jung, Anthony H. Futerman. LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFa-converting enzyme. FEBS Lett. 2015 Aug 4.


18. Perisic Matic L, Rykaczewska U, Razuvaev A, Sabater-Lleal M, Lengquist M, Miller CL, Ericsson I, Röhl S, Kronqvist M, Aldi S, MagnÚ J, Paloschi V, Vesterlund M, Li Y, Jin H, Diez MG, Roy J, Baldassarre D, Veglia F, Humphries SE, de Faire U, Tremoli E, Odeberg J, Vukojevic V, Lehtiö J, Maegdefessel L, Ehrenborg E, Paulsson-Berne G, Hansson GK, Lindeman JH, Eriksson P, Quertermous, T, Hamsten A, Hedin U. Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1947-61.


19. Pirault J, Polyzos KA, Petri MH, Ketelhuth DFJ, Bäck M, Hansson GK. The inflammatory cytokine interferon-gamma inhibits sortilin-1 expression in hepatocytes via the JAK/STAT pathway. Eur J Immunol. 2017 Nov;47(11):1918-1924.


20. Saroha, A., Y. Pewzner-Jung, N.S. Ferreira, P. Sharma, Y. Jouan, S.L. Kelly, E. Feldmesser, A.H. Merrill, F. Trottein, C. Paget, K.S. Lang, and A.H. Futerman. Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis. Front Immunol. 2017, 8:1386. doi:10.3389/fimmu.2017.01386.


21 Shepard, H.M., Phillips, G.L., Thanos, C.D. and Feldmann, M. Developments in therapy with monoclonal antibodies and related proteins. Clin. Med. 2017, 17: 3: 220-237.


22. Söderström LÅ, Jin H, Caravaca AS, Klement ML, Li Y, Gisterå A, Hedin U, Maegdefessel L, Hansson GK, Olofsson PS. Increased Carotid Artery Lesion Inflammation Upon Treatment With the CD137 Agonistic Antibody 2A. Circ J. 2017 Nov 24;81(12):1945-1952.


23. Strodthoff D, Ma Z, Wirstr÷m T, Strawbridge RJ, Ketelhuth DF, Engel D, Clarke R, Falkmer S, Hamsten A, Hansson GK, Bj÷rklund A, Lundberg AM. Toll-Like Receptor 3 Influences Glucose Homeostasis and ▀-Cell Insulin Secretion. Diabetes. 2015 Oct;64(10):3425-38.


24. Udalova, I, Mantovani, A. and Feldmann, M. Macrophage heterogeneity in the context of rheumatic diseases. Nat Rev Rheumatol. 2016, 12(8): 472-85.


25. Udalova, I., Monaco, C., Nanchahal, J. and Feldmann, M. Anti-TNF Therapy. Microbiology Spectrum. 2016, 4(4): 1-11.


The following sentence must be included in project publications:

The research leading to these results has received funding from the European Union Seventh Framework Programme [FP7-2007-2013] under grant agreement n° HEALTH-F2-2013-602222 “Targeting novel lipid pathways for treatment of cardiovascular disease“ (Athero-Flux).