Project publications


1. Araújo JR, Tomas J, Brenner C, Sansonetti PJ. Impact of high-fat diet on the intestinal microbiota and small intestinal physiology before and after the onset of obesity. Biochimie. 2017;141:97-106.

 

2. Tazi A, Araújo JR, Mulet C, Arena ET, Nigro G, Pédron T, Sansonetti PJ. Disentangling host-microbiota regulation of lipid secretion by enterocytes: insights from Lactobacillus paracasei and Escherichia coli. Mbio. 2018;9(5). pii: e01493-18.

 

3. Assinger A, Wang Y, Butler LM, Hansson GK, Yan ZQ, Söderberg-Nauclér C, Ketelhuth DF. Apolipoprotein B100 danger-associated signal 1 (ApoBDS-1) triggers platelet activation and boosts platelet-leukocyte proinflammatory responses. Thromb Haemost. 2014 Aug;112(2):332-41.

 

4. Eken SM, Jin H, Chernogubova E, Li Y, Simon N, Sun C, Korzunowicz G, Busch A, Bäcklund A, Österholm C, Razuvaev A, Renné T, Eckstein HH, Pelisek J, Eriksson P, González Díez M, Perisic Matic L, Schellinger IN, Raaz U, Leeper NJ, Hansson GK, Berne G, Hedin U, Maegdefessel L. MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions. Circ Res. 2017 Feb 17;120(4):633-644.

 

5. Forteza MJ, Polyzos KA, Baumgartner R, Suur BE, Mussbacher M, Johansson DK, Hermansson A, Hansson GK, Ketelhuth DFJ. Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice. Front Immunol. 2018 May 7;9:950.

 

6. Gisterå A, Hansson GK. The immunology of atherosclerosis. Nat Rev Nephrol. 2017 Jun;13(6):368-380.

 

7. Gisterå A, Hermansson A, Strodthoff D, Klement ML, Hedin U, Fredrikson GN, Nilsson J, Hansson GK, Ketelhuth DF. Vaccination against T-cell epitopes of native ApoB100 reduces vascular inflammation and disease in a humanized mouse model of atherosclerosis. J Intern Med. 2017 Apr;281(4):383-397.

 

8. Gisterå A, Klement ML, Polyzos KA, Mailer RKW, Duhlin A, Karlsson MCI, Ketelhuth DFJ, Hansson GK. Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice. Circulation. 2018 Nov 27;138(22):2513-2526.

 

9. Johansson ME, Ulleryd MA, Bernardi A, Lundberg AM, Andersson A, Folkersen L, Fogelstrand L, Islander U, Yan ZQ, Hansson GK. α7 Nicotinic Acetylcholine Receptor Is Expressed in Human Atherosclerosis and Inhibits Disease in Mice. Arterioscler Thromb Vasc Biol. 2014 Oct 16.

 

10. Johansson ME, Zhang XY, Edfeldt K, Lundberg AM, Levin MC, Borén J, Li W, Yuan XM, Folkersen L, Eriksson P, Hedin U, Low H, Sviridov D, Rios FJ, Hansson GK, Yan ZQ. Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic mice. Eur J Immunol. 2014. Oct;44(10):3081-92.

 

11. Karadimou G, Folkersen L, Berg M, Perisic L, Discacciati A, Roy J, Hansson GK, Persson J, Paulsson-Berne G. Low TLR7 gene expression in atherosclerotic plaques is associated with major adverse cardio- and cerebrovascular events. Cardiovasc Res. 2017 Jan;113(1):30-39.

 

12. Kiamehr M, Viiri LE, Vihervaara T, Koistinen KM, Hilvo M, Ekroos K, Käkelä R, Aalto-Setälä K. Lipidomic profiling of patient-specific induced pluripotent stem cell-derived hepatocyte-like cells. Dis Model Mech. 2017, 10(9):1141-1153. [Epub 2017 Jul 21].

 

13. Kiamehr M, Alexanova A, Viiri LE, Heiskanen L, Vihervaara T, Kauhanen D, Ekroos K, Laaksonen R, Käkelä R, Aalto-Setälä K. hiPSC-derived hepatocytes closely mimic the lipid profile of primary hepatocytes: A future personalised cell model for studying the lipid metabolism of the liver. J Cell Physiol. 2018;1–18.

 

14. Kiamehr M. Induced pluripotent stem cell-derived hepatocyte-like cells. The lipid status in differentiation, functionality, and de-differentiation of hepatic cells. Tampere University Dissertations 5.

 

15. Lee, G., Espirito Santo, A.I., Zwingenberger, S., Cai, L, Vogl, T., Feldmann, M., Horwood, N., Chan, J. and Nanchahal, J. Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert. Proc. Natl. Acad. Sci. USA. 2018: E4463-E4472.

 

16. Lundberg AK, Jonasson L, Hansson GK, Mailer RKW. Activation-induced FOXP3 isoform profile in peripheral CD4+ T cells is associated with coronary artery disease. Atherosclerosis. 2017 Dec;267:27-33.

 

17. Mailer RKW, Gisterå A, Polyzos KA, Ketelhuth DFJ, Hansson GK. Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population. Sci Rep. 2017 Nov 15;7(1):15655. PMC5688061.

 

18. Mailer RKW, Gisterå A, Polyzos KA, Ketelhuth DFJ, Hansson GK. Hypercholesterolemia Induces Differentiation of Regulatory T Cells in the Liver. Circ Res. 2017 May 26;120(11):1740-1753.

 

19. Nanchahal, J., Ball, C., Swettenham, J., Dutton, S., Barber, V., Black, J., Copsey, B., Dritsaki, M., Taylor, P., Gray, A., Feldmann, M. and Lamb, S. Study protocol: a multi-centre, double blind, randomised, placebo-controlled, parallel group, phase II trial (RIDD) to determine the efficacy of intra-nodular injection of anti-TNF to control disease progression in early Dupuytren’s disease, with an embedded dose response study. Wellcome Open Research, 2017, 2: 37.

 

20. Stefano Manzini, Leena E. Viiri, Suvi Marttila, Katriina Aalto-Setälä. A Comparative View on Easy to Deploy non-Integrating Methods for Patient-Specific iPSC Production. Stem Cell Reviews and Reports. 2015Sept; pp 1-9.

 

21. Mohammad Ali, Ashish Saroha, Yael Pewzner-Jung, Anthony H. Futerman. LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFa-converting enzyme. FEBS Lett. 2015 Aug 4.

 

22. Paget C, Deng S, Soulard D, Priestman DA, Speca S, von Gerichten J, Speak AO, Saroha A, Pewzner-Jung Y, Futerman AH, Mallevaey T, Faveeuw C, Gu X, Platt FM, Sandhoff R, Trottein F. (2019). TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells. PLoS Biol. 2019 Mar 1;17(3):e3000169. doi: 10.1371/journal.pbio.3000169. eCollection 2019 Mar.

 

23. Perisic Matic L, Rykaczewska U, Razuvaev A, Sabater-Lleal M, Lengquist M, Miller CL, Ericsson I, Röhl S, Kronqvist M, Aldi S, Magné J, Paloschi V, Vesterlund M, Li Y, Jin H, Diez MG, Roy J, Baldassarre D, Veglia F, Humphries SE, de Faire U, Tremoli E, Odeberg J, Vukojevic V, Lehtiö J, Maegdefessel L, Ehrenborg E, Paulsson-Berne G, Hansson GK, Lindeman JH, Eriksson P, Quertermous, T, Hamsten A, Hedin U. Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1947-61.

 

24. Pirault J, Polyzos KA, Petri MH, Ketelhuth DFJ, Bäck M, Hansson GK. The inflammatory cytokine interferon-gamma inhibits sortilin-1 expression in hepatocytes via the JAK/STAT pathway. Eur J Immunol. 2017 Nov;47(11):1918-1924.

 

25. Saroha, A., Y. Pewzner-Jung, N.S. Ferreira, P. Sharma, Y. Jouan, S.L. Kelly, E. Feldmesser, A.H. Merrill, F. Trottein, C. Paget, K.S. Lang, and A.H. Futerman. Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis. Front Immunol. 2017, 8:1386. doi:10.3389/fimmu.2017.01386.

 

26. Shepard, H.M., Phillips, G.L., Thanos, C.D. and Feldmann, M. Developments in therapy with monoclonal antibodies and related proteins. Clin. Med. 2017, 17: 3: 220-237.

 

27. Söderström LÅ, Jin H, Caravaca AS, Klement ML, Li Y, Gisterå A, Hedin U, Maegdefessel L, Hansson GK, Olofsson PS. Increased Carotid Artery Lesion Inflammation Upon Treatment With the CD137 Agonistic Antibody 2A. Circ J. 2017 Nov 24;81(12):1945-1952.

 

28. Strodthoff D, Ma Z, Wirström T, Strawbridge RJ, Ketelhuth DF, Engel D, Clarke R, Falkmer S, Hamsten A, Hansson GK, Björklund A, Lundberg AM. Toll-Like Receptor 3 Influences Glucose Homeostasis and ß-Cell Insulin Secretion. Diabetes. 2015 Oct;64(10):3425-38.

 

29. Udalova, I, Mantovani, A. and Feldmann, M. Macrophage heterogeneity in the context of rheumatic diseases. Nat Rev Rheumatol. 2016, 12(8): 472-85.

 

30. Udalova, I., Monaco, C., Nanchahal, J. and Feldmann, M. Anti-TNF Therapy. Microbiology Spectrum. 2016, 4(4): 1-11.

 

31. Leena E. Viiri, Tommi Rantapero, Mostafa Kiamehr, Anna Alexanova, Mikko Oittinen, Keijo Viiri, Henri Niskanen, Matti Nykter, Minna U. Kaikkonen, Katriina Aalto-Setälä. Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation. Scientific Reports. (2019) 9:3562.

 

32. Joly AL, Seitz C, Liu S, Kuznetsov NV, Gertow K, Westerberg LS, Paulsson-Berne G, Hansson GK, Andersson J. Alternative Splicing of FOXP3 Controls Regulatory T Cell Effector Functions and Is Associated With Human Atherosclerotic Plaque Stability. Circ Res. 2018 May 11;122(10):1385-1394.

 

33. Jiang XT, Wang FL, Wang YJ, Gisterå A, Joy Roy J, Paulsson-Berne G, Hedin U, Lerman A, Hansson GK, Herrmann J and Yan ZQ. Inflammasome-Driven Interleukin-1α and -1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia and Plaque Complexity. JACC. 2019 in press

 


The following sentence must be included in project publications:
The research leading to these results has received funding from the European Union Seventh Framework Programme [FP7-2007-2013] under grant agreement n° HEALTH-F2-2013-602222 “Targeting novel lipid pathways for treatment of cardiovascular disease“ (Athero-Flux).